Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths
نویسندگان
چکیده
منابع مشابه
Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths
B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve, e.g., base substitution, codon insertion and deletion, often in association with an isotype switch. Investigations of antibody evolution define modes whereby particular antibody responses are able to f...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.01433